BRD-K95760042_2512-0754_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K95760042_2512-0754_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AQP9 aquaporin 9
BID BH3 interacting domain death agonist
C2CD2 C2 calcium-dependent domain containing 2
CCNA1 cyclin A1
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CD99 CD99 molecule
CFD complement factor D (adipsin)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
CYBRD1 cytochrome b reductase 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DMXL2 Dmx-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMPR guanosine monophosphate reductase
GREM1 gremlin 1, DAN family BMP antagonist
HMGB2 high mobility group box 2
HRG histidine-rich glycoprotein
HRSP12 heat-responsive protein 12
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KLK5 kallikrein-related peptidase 5
LGALS3 lectin, galactoside-binding, soluble, 3
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
MNDA myeloid cell nuclear differentiation antigen
MT1M metallothionein 1M
MT1X metallothionein 1X
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
OSR2 odd-skipped related transciption factor 2
PCP4 Purkinje cell protein 4
PDZD2 PDZ domain containing 2
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
RNF130 ring finger protein 130
SERINC5 serine incorporator 5
SFRP4 secreted frizzled-related protein 4
SLC31A2 solute carrier family 31 (copper transporter), member 2
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
STAT1 signal transducer and activator of transcription 1, 91kDa
TBC1D31 TBC1 domain family, member 31
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TNNT1 troponin T type 1 (skeletal, slow)
TPPP3 tubulin polymerization-promoting protein family member 3
TXNL4B thioredoxin-like 4B
WT1 Wilms tumor 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP11B ATPase, class VI, type 11B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAX BCL2-associated X protein
BEX1 brain expressed, X-linked 1
BZW2 basic leucine zipper and W2 domains 2
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CD24 CD24 molecule
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL6 chemokine (C-X-C motif) ligand 6
DICER1 dicer 1, ribonuclease type III
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EDNRB endothelin receptor type B
ENOPH1 enolase-phosphatase 1
EZR ezrin
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IGFBP4 insulin-like growth factor binding protein 4
IL32 interleukin 32
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LMO4 LIM domain only 4
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP7 matrix metallopeptidase 7
MTF2 metal response element binding transcription factor 2
MYO6 myosin VI
NEBL nebulette
PDE4D phosphodiesterase 4D, cAMP-specific
PFKP phosphofructokinase, platelet
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLAC8 placenta-specific 8
PROM1 prominin 1
RHOB ras homolog family member B
RNF167 ring finger protein 167
SEPP1 selenoprotein P, plasma, 1
SEPT9 septin 9
SFTPC surfactant protein C
SIX1 SIX homeobox 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAP1 small ArfGAP 1
STX1A syntaxin 1A (brain)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
VAMP8 vesicle-associated membrane protein 8
VCAM1 vascular cell adhesion molecule 1
YME1L1 YME1-like 1 ATPase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon