BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
BMP2 bone morphogenetic protein 2
CPB1 carboxypeptidase B1 (tissue)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GPR183 G protein-coupled receptor 183
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
JAG1 jagged 1
KIF14 kinesin family member 14
LEFTY1 left-right determination factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MYC v-myc avian myelocytomatosis viral oncogene homolog
OXSR1 oxidative stress responsive 1
PRKCB protein kinase C, beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASA4 RAS p21 protein activator 4
RCAN1 regulator of calcineurin 1
SDC2 syndecan 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
THBD thrombomodulin
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TSPYL5 TSPY-like 5

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C10ORF10 chromosome 10 open reading frame 10
CDK1 cyclin-dependent kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM129A family with sequence similarity 129, member A
GNAS GNAS complex locus
HIST1H4C histone cluster 1, H4c
IFI6 interferon, alpha-inducible protein 6
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
KIAA0101 KIAA0101
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
PEG10 paternally expressed 10
PON3 paraoxonase 3
SMAD1 SMAD family member 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB1 tribbles pseudokinase 1
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZWINT ZW10 interacting kinetochore protein