BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANXA3 annexin A3
APOD apolipoprotein D
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHRDL1 chordin-like 1
COCH cochlin
CRISP3 cysteine-rich secretory protein 3
DCLK1 doublecortin-like kinase 1
DHDDS dehydrodolichyl diphosphate synthase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
ERAP2 endoplasmic reticulum aminopeptidase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
LAMB3 laminin, beta 3
LPL lipoprotein lipase
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MT1E metallothionein 1E
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPL periplakin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTRF polymerase I and transcript release factor
RAP2A RAP2A, member of RAS oncogene family
RND3 Rho family GTPase 3
SEC62 SEC62 homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SPINK1 serine peptidase inhibitor, Kazal type 1
STAB1 stabilin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRA2A transformer 2 alpha homolog (Drosophila)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AHR aryl hydrocarbon receptor
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
BAMBI BMP and activin membrane-bound inhibitor
BGN biglycan
C8ORF4 chromosome 8 open reading frame 4
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRIP1 cysteine-rich protein 1 (intestinal)
DCK deoxycytidine kinase
DERA deoxyribose-phosphate aldolase (putative)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
ENO1 enolase 1, (alpha)
FANCI Fanconi anemia, complementation group I
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
GAS1 growth arrest-specific 1
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HSPA1A heat shock 70kDa protein 1A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KRT19 keratin 19, type I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM4 minichromosome maintenance complex component 4
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
MTERF3 mitochondrial transcription termination factor 3
MYH10 myosin, heavy chain 10, non-muscle
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
PDE4B phosphodiesterase 4B, cAMP-specific
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB15 RAB15, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SLC16A4 solute carrier family 16, member 4
SNAP25 synaptosomal-associated protein, 25kDa
SNX10 sorting nexin 10
SPAG4 sperm associated antigen 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SULF1 sulfatase 1
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WFDC2 WAP four-disulfide core domain 2
ZWINT ZW10 interacting kinetochore protein