BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
AKAP8L A kinase (PRKA) anchor protein 8-like
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
CRYAB crystallin, alpha B
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FLG filaggrin
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GBP2 guanylate binding protein 2, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
H2BFS H2B histone family, member S (pseudogene)
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT20 keratin 20, type I
KRT81 keratin 81, type II
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MMP3 matrix metallopeptidase 3
MT1E metallothionein 1E
MT1X metallothionein 1X
MUC2 mucin 2, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKTR natural killer cell triggering receptor
OLFM4 olfactomedin 4
PEG10 paternally expressed 10
PLK2 polo-like kinase 2
PTPRC protein tyrosine phosphatase, receptor type, C
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
STAB1 stabilin 1
STK17A serine/threonine kinase 17a
THBS1 thrombospondin 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS3 transmembrane protease, serine 3
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TRBC1 T cell receptor beta constant 1
TRIM22 tripartite motif containing 22
TSPYL5 TSPY-like 5
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ADGRG6 adhesion G protein-coupled receptor G6
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
ATXN1 ataxin 1
AURKB aurora kinase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
CPD carboxypeptidase D
CST3 cystatin C
CTSH cathepsin H
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EGFL6 EGF-like-domain, multiple 6
FBXO5 F-box protein 5
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FOXC1 forkhead box C1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HDAC9 histone deacetylase 9
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H4C histone cluster 1, H4c
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOPX HOP homeobox
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGFBP7 insulin-like growth factor binding protein 7
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
KRT13 keratin 13, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MARCKSL1 MARCKS-like 1
MEIS1 Meis homeobox 1
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MSLN mesothelin
MYH10 myosin, heavy chain 10, non-muscle
NUSAP1 nucleolar and spindle associated protein 1
ORM1 orosomucoid 1
PGM1 phosphoglucomutase 1
PPAP2B phosphatidic acid phosphatase type 2B
PSCA prostate stem cell antigen
PSRC1 proline/serine-rich coiled-coil 1
RAB13 RAB13, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
RRM2 ribonucleotide reductase M2
RUFY3 RUN and FYVE domain containing 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPB surfactant protein B
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPEN spen family transcriptional repressor
STAG2 stromal antigen 2
STAU1 staufen double-stranded RNA binding protein 1
STK39 serine threonine kinase 39
STMN1 stathmin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B
ZWINT ZW10 interacting kinetochore protein