BRD-K94580036_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K94580036_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTL6A actin-like 6A
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
CA2 carbonic anhydrase II
CAV2 caveolin 2
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CHGA chromogranin A
CHGB chromogranin B
CLCA1 chloride channel accessory 1
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXORF57 chromosome X open reading frame 57
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EDN1 endothelin 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FXR1 fragile X mental retardation, autosomal homolog 1
GCG glucagon
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
INSM1 insulinoma-associated 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDR kinase insert domain receptor
KRT20 keratin 20, type I
LGALS4 lectin, galactoside-binding, soluble, 4
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MET MET proto-oncogene, receptor tyrosine kinase
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MUC2 mucin 2, oligomeric mucus/gel-forming
NBEA neurobeachin
NMU neuromedin U
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKP2 plakophilin 2
PLCB4 phospholipase C, beta 4
PLS1 plastin 1
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCGB1D2 secretoglobin, family 1D, member 2
SCGN secretagogin, EF-hand calcium binding protein
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SI sucrase-isomaltase (alpha-glucosidase)
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPINK4 serine peptidase inhibitor, Kazal type 4
ST18 suppression of tumorigenicity 18, zinc finger
SYBU syntabulin (syntaxin-interacting)
TESK1 testis-specific kinase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOX3 TOX high mobility group box family member 3
TSPAN12 tetraspanin 12
TYRP1 tyrosinase-related protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AK4 adenylate kinase 4
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATXN1 ataxin 1
BST2 bone marrow stromal cell antigen 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD46 CD46 molecule, complement regulatory protein
CDA cytidine deaminase
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CRIP1 cysteine-rich protein 1 (intestinal)
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
EIF5A eukaryotic translation initiation factor 5A
FAM198B family with sequence similarity 198, member B
FBLN5 fibulin 5
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
IL1RN interleukin 1 receptor antagonist
IL6ST interleukin 6 signal transducer
ISLR immunoglobulin superfamily containing leucine-rich repeat
KCTD12 potassium channel tetramerization domain containing 12
KLK11 kallikrein-related peptidase 11
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MX2 MX dynamin-like GTPase 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PEG3 paternally expressed 3
PGD phosphogluconate dehydrogenase
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
RAD23B RAD23 homolog B (S. cerevisiae)
RANBP2 RAN binding protein 2
RHCG Rh family, C glycoprotein
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED2 transmembrane emp24 domain trafficking protein 2
TPD52L1 tumor protein D52-like 1
WDR1 WD repeat domain 1
ZNF586 zinc finger protein 586