BRD-K94390040_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K94390040_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AQP1 aquaporin 1 (Colton blood group)
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLU clusterin
COMP cartilage oligomeric matrix protein
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FDPS farnesyl diphosphate synthase
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LGALS2 lectin, galactoside-binding, soluble, 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
MSMO1 methylsterol monooxygenase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PMM1 phosphomannomutase 1
RGS1 regulator of G-protein signaling 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TRIB3 tribbles pseudokinase 3
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
COL13A1 collagen, type XIII, alpha 1
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM3C family with sequence similarity 3, member C
FOSL1 FOS-like antigen 1
GNAS GNAS complex locus
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
LEF1 lymphoid enhancer-binding factor 1
MIR22HG MIR22 host gene
NOP16 NOP16 nucleolar protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RGCC regulator of cell cycle
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A