BRD-K94176593_TWS-119_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K94176593_TWS-119_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APLP2 amyloid beta (A4) precursor-like protein 2
ASRGL1 asparaginase like 1
ASS1 argininosuccinate synthase 1
BRD3 bromodomain containing 3
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C3 complement component 3
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COL4A5 collagen, type IV, alpha 5
CTSB cathepsin B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
DDR1 discoidin domain receptor tyrosine kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DPP4 dipeptidyl-peptidase 4
DTX4 deltex 4, E3 ubiquitin ligase
ECH1 enoyl CoA hydratase 1, peroxisomal
EPCAM epithelial cell adhesion molecule
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
GNAS GNAS complex locus
GPC1 glypican 1
GPX1 glutathione peroxidase 1
GSN gelsolin
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCTD12 potassium channel tetramerization domain containing 12
LAMA5 laminin, alpha 5
LIPG lipase, endothelial
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MUC1 mucin 1, cell surface associated
NFIB nuclear factor I/B
NID1 nidogen 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
PFKL phosphofructokinase, liver
PLXNB1 plexin B1
PPL periplakin
PROS1 protein S (alpha)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A4RG SLC2A4 regulator
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SYNE2 spectrin repeat containing, nuclear envelope 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ACSL1 acyl-CoA synthetase long-chain family member 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
CKAP4 cytoskeleton-associated protein 4
CLMN calmin (calponin-like, transmembrane)
CRCT1 cysteine-rich C-terminal 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
ICAM3 intercellular adhesion molecule 3
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
KLF2 Kruppel-like factor 2
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MOK MOK protein kinase
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE4DIP phosphodiesterase 4D interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RHCG Rh family, C glycoprotein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY2 sprouty homolog 2 (Drosophila)
SQLE squalene epoxidase
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPPP3 tubulin polymerization-promoting protein family member 3
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)