BRD-K94012289_OSI-027_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K94012289_OSI-027_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSF2 acyl-CoA synthetase family member 2
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANOS1 anosmin 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BTBD3 BTB (POZ) domain containing 3
C6ORF48 chromosome 6 open reading frame 48
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CLIC5 chloride intracellular channel 5
COBL cordon-bleu WH2 repeat protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DEPTOR DEP domain containing MTOR-interacting protein
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
FBXO21 F-box protein 21
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
GATA2 GATA binding protein 2
GPC4 glypican 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSDMB gasdermin B
GSTK1 glutathione S-transferase kappa 1
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
HMGA2 high mobility group AT-hook 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LETMD1 LETM1 domain containing 1
LXN latexin
LY75 lymphocyte antigen 75
MAGED1 melanoma antigen family D1
MAN1C1 mannosidase, alpha, class 1C, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MPO myeloperoxidase
MTSS1 metastasis suppressor 1
MYO5C myosin VC
MYOF myoferlin
NBR1 neighbor of BRCA1 gene 1
NET1 neuroepithelial cell transforming 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PGAP3 post-GPI attachment to proteins 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PROM1 prominin 1
PRSS23 protease, serine, 23
PTX3 pentraxin 3, long
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SSFA2 sperm specific antigen 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK32B serine/threonine kinase 32B
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
UBA7 ubiquitin-like modifier activating enzyme 7
VAMP8 vesicle-associated membrane protein 8
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)
ZNF586 zinc finger protein 586
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AK4 adenylate kinase 4
ARG2 arginase 2
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF24 chromosome 20 open reading frame 24
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CHN1 chimerin 1
CXCL14 chemokine (C-X-C motif) ligand 14
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EGLN3 egl-9 family hypoxia-inducible factor 3
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EREG epiregulin
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
H2AFZ H2A histone family, member Z
HOPX HOP homeobox
HSPA4L heat shock 70kDa protein 4-like
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MICB MHC class I polypeptide-related sequence B
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PITX1 paired-like homeodomain 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PSPH phosphoserine phosphatase
RANBP1 RAN binding protein 1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SUB1 SUB1 homolog (S. cerevisiae)
TFDP1 transcription factor Dp-1
TIGAR TP53 induced glycolysis regulatory phosphatase
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZNF395 zinc finger protein 395