BRD-K94012289_OSI-027_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K94012289_OSI-027_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ASPH aspartate beta-hydroxylase
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCR breakpoint cluster region
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
GATA3 GATA binding protein 3
GLIPR1 GLI pathogenesis-related 1
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO13 importin 13
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM5D lysine (K)-specific demethylase 5D
LDHB lactate dehydrogenase B
LOX lysyl oxidase
MEF2A myocyte enhancer factor 2A
METTL7A methyltransferase like 7A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
NDRG1 N-myc downstream regulated 1
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE4B phosphodiesterase 4B, cAMP-specific
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKCH protein kinase C, eta
PROM1 prominin 1
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SERINC1 serine incorporator 1
SLC38A2 solute carrier family 38, member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STX7 syntaxin 7
SYNE2 spectrin repeat containing, nuclear envelope 2
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM45A transmembrane protein 45A
TRAF3IP2 TRAF3 interacting protein 2
TSC22D3 TSC22 domain family, member 3
VCAN versican
YBX1 Y box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COCH cochlin
CTSH cathepsin H
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
G0S2 G0/G1 switch 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JMJD6 jumonji domain containing 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MMP9 matrix metallopeptidase 9
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPTX2 neuronal pentraxin II
NSG1 neuron specific gene family member 1
NUP62 nucleoporin 62kDa
ODC1 ornithine decarboxylase 1
QPRT quinolinate phosphoribosyltransferase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SPEN spen family transcriptional repressor
SPON1 spondin 1, extracellular matrix protein
TBX2 T-box 2
TFRC transferrin receptor
THBD thrombomodulin
THBS1 thrombospondin 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMP1 TIMP metallopeptidase inhibitor 1
TUBB6 tubulin, beta 6 class V
XIST X inactive specific transcript (non-protein coding)