BRD-K94012289_OSI-027_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K94012289_OSI-027_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
C1R complement component 1, r subcomponent
C7 complement component 7
CCNG2 cyclin G2
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DEPTOR DEP domain containing MTOR-interacting protein
EIF5A eukaryotic translation initiation factor 5A
FAM46A family with sequence similarity 46, member A
FZD7 frizzled class receptor 7
GAL galanin/GMAP prepropeptide
GBP2 guanylate binding protein 2, interferon-inducible
GPM6B glycoprotein M6B
HBP1 HMG-box transcription factor 1
KIAA0753 KIAA0753
LMBRD1 LMBR1 domain containing 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MXI1 MAX interactor 1, dimerization protein
NFIB nuclear factor I/B
PBX3 pre-B-cell leukemia homeobox 3
PCNA proliferating cell nuclear antigen
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB13 RAB13, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPR translocated promoter region, nuclear basket protein
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
VCAN versican
WISP2 WNT1 inducible signaling pathway protein 2
YBX3 Y box binding protein 3
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMD1 adenosylmethionine decarboxylase 1
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN4 claudin 4
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EMX2 empty spiracles homeobox 2
EZR ezrin
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
LDLRAD4 low density lipoprotein receptor class A domain containing 4
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
NEBL nebulette
PFN2 profilin 2
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STC1 stanniocalcin 1
TUBB2A tubulin, beta 2A class IIa