BRD-K94012289_OSI-027_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K94012289_OSI-027_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADCK3 aarF domain containing kinase 3
ADIRF adipogenesis regulatory factor
BHLHE41 basic helix-loop-helix family, member e41
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BD histone cluster 1, H2bd
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KLK2 kallikrein-related peptidase 2
LUC7L3 LUC7-like 3 (S. cerevisiae)
NPIPB3 nuclear pore complex interacting protein family, member B3
OBSL1 obscurin-like 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRSS21 protease, serine, 21 (testisin)
PTN pleiotrophin
RPL31 ribosomal protein L31
SEPP1 selenoprotein P, plasma, 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC44A4 solute carrier family 44, member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATA20 spermatogenesis associated 20
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACAT2 acetyl-CoA acetyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ECT2 epithelial cell transforming 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
GARS glycyl-tRNA synthetase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGFBP4 insulin-like growth factor binding protein 4
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTTG1 pituitary tumor-transforming 1
RBBP8 retinoblastoma binding protein 8
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SHCBP1 SHC SH2-domain binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC2 stanniocalcin 2
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
YARS tyrosyl-tRNA synthetase
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein