BRD-K93788137_PF-431396_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K93788137_PF-431396_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOD apolipoprotein D
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
CERS6 ceramide synthase 6
COL11A1 collagen, type XI, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYTL1 cytokine-like 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6B glycoprotein M6B
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RB interleukin 17 receptor B
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KRT5 keratin 5, type II
MAOB monoamine oxidase B
MATN2 matrilin 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEF2C myocyte enhancer factor 2C
MSRA methionine sulfoxide reductase A
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
NPTX2 neuronal pentraxin II
PDZK1 PDZ domain containing 1
PLP1 proteolipid protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
RBP4 retinol binding protein 4, plasma
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
SYT1 synaptotagmin I
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AURKA aurora kinase A
C1ORF54 chromosome 1 open reading frame 54
C2CD5 C2 calcium-dependent domain containing 5
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL9 chemokine (C-X-C motif) ligand 9
CYB561 cytochrome b561
DKK3 dickkopf WNT signaling pathway inhibitor 3
EVI2A ecotropic viral integration site 2A
FAP fibroblast activation protein, alpha
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GPATCH8 G patch domain containing 8
HNMT histamine N-methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
KIAA0485 uncharacterized LOC57235
KYNU kynureninase
LOC100272216 uncharacterized LOC100272216
LY96 lymphocyte antigen 96
MNDA myeloid cell nuclear differentiation antigen
NCOA3 nuclear receptor coactivator 3
PBX1 pre-B-cell leukemia homeobox 1
PDLIM5 PDZ and LIM domain 5
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIN2 Ras and Rab interactor 2
S100A9 S100 calcium binding protein A9
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX11 SRY (sex determining region Y)-box 11
SYNJ2 synaptojanin 2
TBC1D31 TBC1 domain family, member 31
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
VEGFC vascular endothelial growth factor C
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF160 zinc finger protein 160
ZNF451 zinc finger protein 451