BRD-K93788137_PF-431396_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K93788137_PF-431396_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAT catalase
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DPP4 dipeptidyl-peptidase 4
EGFR epidermal growth factor receptor
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
GDI2 GDP dissociation inhibitor 2
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IVNS1ABP influenza virus NS1A binding protein
LAMA4 laminin, alpha 4
LRMP lymphoid-restricted membrane protein
MYOF myoferlin
NDRG1 N-myc downstream regulated 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PPL periplakin
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAP prosaposin
PSCA prostate stem cell antigen
RAB31 RAB31, member RAS oncogene family
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
BACE2 beta-site APP-cleaving enzyme 2
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNN3 calponin 3, acidic
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LMCD1 LIM and cysteine-rich domains 1
MOK MOK protein kinase
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM2 PDZ and LIM domain 2 (mystique)
PIPOX pipecolic acid oxidase
PNMA2 paraneoplastic Ma antigen 2
PTMA prothymosin, alpha
PYCR1 pyrroline-5-carboxylate reductase 1
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TNC tenascin C