BRD-K93788137_PF-431396_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K93788137_PF-431396_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
EAPP E2F-associated phosphoprotein
ESR1 estrogen receptor 1
FDXR ferredoxin reductase
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
ISG15 ISG15 ubiquitin-like modifier
ITFG1 integrin alpha FG-GAP repeat containing 1
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
MAB21L1 mab-21-like 1 (C. elegans)
MAGEA3 melanoma antigen family A3
MANSC1 MANSC domain containing 1
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
NPDC1 neural proliferation, differentiation and control, 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PIP prolactin-induced protein
PLCB4 phospholipase C, beta 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRUNE2 prune homolog 2 (Drosophila)
RORA RAR-related orphan receptor A
RPS27L ribosomal protein S27-like
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SIDT2 SID1 transmembrane family, member 2
SLC22A18 solute carrier family 22, member 18
SPTSSA serine palmitoyltransferase, small subunit A
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
STXBP6 syntaxin binding protein 6 (amisyn)
SYBU syntabulin (syntaxin-interacting)
TOB1 transducer of ERBB2, 1
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
C7 complement component 7
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
DENND2D DENN/MADD domain containing 2D
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM64A family with sequence similarity 64, member A
FXYD2 FXYD domain containing ion transport regulator 2
FZD7 frizzled class receptor 7
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPER1 G protein-coupled estrogen receptor 1
IL1R1 interleukin 1 receptor, type I
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
MAL mal, T-cell differentiation protein
MAP7 microtubule-associated protein 7
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEK2 NIMA-related kinase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSRC1 proline/serine-rich coiled-coil 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPRR3 small proline-rich protein 3
TMSB15A thymosin beta 15a
TRIB2 tribbles pseudokinase 2
ZNF22 zinc finger protein 22