BRD-K93725829_ERK inhibitor 11e_SW620_6.0_h_0.5_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_SW620_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSPT2 G1 to S phase transition 2
GSTT1 glutathione S-transferase theta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ITGB1BP1 integrin beta 1 binding protein 1
JCHAIN joining chain of multimeric IgA and IgM
MEF2C myocyte enhancer factor 2C
NARFL nuclear prelamin A recognition factor-like
NMU neuromedin U
ORC1 origin recognition complex, subunit 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRODH proline dehydrogenase (oxidase) 1
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAD51AP1 RAD51 associated protein 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SOD2 superoxide dismutase 2, mitochondrial
STS steroid sulfatase (microsomal), isozyme S
TRIM2 tripartite motif containing 2
UGP2 UDP-glucose pyrophosphorylase 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYTL1 cytokine-like 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
ERLIN1 ER lipid raft associated 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GATA3 GATA binding protein 3
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPC3 glypican 3
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HOMER1 homer scaffolding protein 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INPP1 inositol polyphosphate-1-phosphatase
KLF6 Kruppel-like factor 6
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMNA lamin A/C
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MGP matrix Gla protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
ODC1 ornithine decarboxylase 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PPARG peroxisome proliferator-activated receptor gamma
PRR7 proline rich 7 (synaptic)
PRSS3 protease, serine, 3
RBMS1 RNA binding motif, single stranded interacting protein 1
S100A11 S100 calcium binding protein A11
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPX sushi-repeat containing protein, X-linked
SVIL supervillin
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TM4SF1 transmembrane 4 L six family member 1
TSPAN4 tetraspanin 4
UBE2S ubiquitin-conjugating enzyme E2S