BRD-K93725829_ERK inhibitor 11e_HT29_6.0_h_0.5_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

41 genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_HT29_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ARID5B AT rich interactive domain 5B (MRF1-like)
CD99 CD99 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
DHCR24 24-dehydrocholesterol reductase
EFNA1 ephrin-A1
MAOA monoamine oxidase A
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
RPS4Y1 ribosomal protein S4, Y-linked 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CXCL13 chemokine (C-X-C motif) ligand 13
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
LAMC2 laminin, gamma 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
TPD52 tumor protein D52