BRD-K93725829_ERK inhibitor 11e_HT29_24.0_h_0.5_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_HT29_24.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMACR alpha-methylacyl-CoA racemase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANOS1 anosmin 1
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAT catalase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EXPH5 exophilin 5
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FGG fibrinogen gamma chain
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GOLPH3L golgi phosphoprotein 3-like
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI6 interferon, alpha-inducible protein 6
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IRF9 interferon regulatory factor 9
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KLHDC2 kelch domain containing 2
LBH limb bud and heart development
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MB myoglobin
NEB nebulin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBLD phenazine biosynthesis-like protein domain containing
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB4 phospholipase C, beta 4
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFTPB surfactant protein B
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TFF3 trefoil factor 3 (intestinal)
TM7SF2 transmembrane 7 superfamily member 2
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36L1 ZFP36 ring finger protein-like 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIM2 absent in melanoma 2
AKAP12 A kinase (PRKA) anchor protein 12
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AREG amphiregulin
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BLMH bleomycin hydrolase
BOP1 block of proliferation 1
CBFB core-binding factor, beta subunit
CCDC86 coiled-coil domain containing 86
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPA centromere protein A
CHSY1 chondroitin sulfate synthase 1
COTL1 coactosin-like F-actin binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM216A family with sequence similarity 216, member A
FASTKD5 FAST kinase domains 5
FKBP11 FK506 binding protein 11, 19 kDa
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HBEGF heparin-binding EGF-like growth factor
HOMER1 homer scaffolding protein 1
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
INPP1 inositol polyphosphate-1-phosphatase
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
JMJD6 jumonji domain containing 6
LGALS1 lectin, galactoside-binding, soluble, 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP1B microtubule-associated protein 1B
MCM10 minichromosome maintenance complex component 10
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCDH9 protocadherin 9
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PITRM1 pitrilysin metallopeptidase 1
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PPIF peptidylprolyl isomerase F
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SMC1A structural maintenance of chromosomes 1A
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STOM stomatin
SYNM synemin, intermediate filament protein
TFPI2 tissue factor pathway inhibitor 2
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRA2B transformer 2 beta homolog (Drosophila)
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing