BRD-K93725829_ERK inhibitor 11e_A375_24.0_h_0.5_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_A375_24.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA4 annexin A4
APOD apolipoprotein D
BLNK B-cell linker
C14ORF132 chromosome 14 open reading frame 132
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CD9 CD9 molecule
CNN1 calponin 1, basic, smooth muscle
COLEC12 collectin sub-family member 12
CRIP2 cysteine-rich protein 2
CRYAB crystallin, alpha B
DDR1 discoidin domain receptor tyrosine kinase 1
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM63A family with sequence similarity 63, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IFI44L interferon-induced protein 44-like
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
LAMP2 lysosomal-associated membrane protein 2
LMOD1 leiomodin 1 (smooth muscle)
LTBP1 latent transforming growth factor beta binding protein 1
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
METRN meteorin, glial cell differentiation regulator
MMP2 matrix metallopeptidase 2
MTMR11 myotubularin related protein 11
MVP major vault protein
NDRG2 NDRG family member 2
NES nestin
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBX1 pre-B-cell leukemia homeobox 1
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIPOX pipecolic acid oxidase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLP1 proteolipid protein 1
PPAP2A phosphatidic acid phosphatase type 2A
PRAF2 PRA1 domain family, member 2
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A4 S100 calcium binding protein A4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRG1 stimulator of chondrogenesis 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E2B solute carrier family 35, member E2B
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
SPATA20 spermatogenesis associated 20
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT11 synaptotagmin XI
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN31 tetraspanin 31
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VGLL4 vestigial-like family member 4
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCNE2 cyclin E2
CD3EAP CD3e molecule, epsilon associated protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLTB clathrin, light chain B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GAL galanin/GMAP prepropeptide
GARS glycyl-tRNA synthetase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
KRT18 keratin 18, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PTGES prostaglandin E synthase
RAP1GAP2 RAP1 GTPase activating protein 2
RUNX3 runt-related transcription factor 3
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1