BRD-K93578426_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K93578426_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
COL15A1 collagen, type XV, alpha 1
CRYZ crystallin, zeta (quinone reductase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSV cathepsin V
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EGLN3 egl-9 family hypoxia-inducible factor 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FZD5 frizzled class receptor 5
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIAA0753 KIAA0753
KRT17 keratin 17, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MELK maternal embryonic leucine zipper kinase
MYOF myoferlin
NCALD neurocalcin delta
NDP Norrie disease (pseudoglioma)
NT5E 5'-nucleotidase, ecto (CD73)
PON2 paraoxonase 2
PSIP1 PC4 and SFRS1 interacting protein 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB25 RAB25, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RNF167 ring finger protein 167
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SSBP2 single-stranded DNA binding protein 2
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM14A transmembrane protein 14A
TPD52 tumor protein D52
UBE2A ubiquitin-conjugating enzyme E2A
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APOD apolipoprotein D
BAX BCL2-associated X protein
BCL6 B-cell CLL/lymphoma 6
C7 complement component 7
CDC25A cell division cycle 25A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYAB crystallin, alpha B
FAM46A family with sequence similarity 46, member A
IL7R interleukin 7 receptor
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAPTM4B lysosomal protein transmembrane 4 beta
LPL lipoprotein lipase
MAGEA1 melanoma antigen family A1
MAGEA3 melanoma antigen family A3
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NXN nucleoredoxin
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRR7 proline rich 7 (synaptic)
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMD4A sterile alpha motif domain containing 4A
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TNNT1 troponin T type 1 (skeletal, slow)
VAT1 vesicle amine transport 1
ZNF512B zinc finger protein 512B
ZNF91 zinc finger protein 91