BRD-K93480852_KN-93_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K93480852_KN-93_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG1 adhesion G protein-coupled receptor G1
AHSP alpha hemoglobin stabilizing protein
AKR1C3 aldo-keto reductase family 1, member C3
ALAS2 5'-aminolevulinate synthase 2
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
AZU1 azurocidin 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
BPHL biphenyl hydrolase-like (serine hydrolase)
C14ORF1 chromosome 14 open reading frame 1
C14ORF132 chromosome 14 open reading frame 132
CA1 carbonic anhydrase I
CD36 CD36 molecule (thrombospondin receptor)
CD46 CD46 molecule, complement regulatory protein
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK14 cyclin-dependent kinase 14
CFD complement factor D (adipsin)
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELANE elastase, neutrophil expressed
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GM2A GM2 ganglioside activator
GRN granulin
GSTA1 glutathione S-transferase alpha 1
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MNDA myeloid cell nuclear differentiation antigen
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDZK1IP1 PDZK1 interacting protein 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTN pleiotrophin
PYCARD PYD and CARD domain containing
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX7 sorting nexin 7
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TM7SF2 transmembrane 7 superfamily member 2
TMEM30B transmembrane protein 30B
TMEM97 transmembrane protein 97
TPP1 tripeptidyl peptidase I
TUBB6 tubulin, beta 6 class V

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AREG amphiregulin
BIK BCL2-interacting killer (apoptosis-inducing)
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
COL5A1 collagen, type V, alpha 1
COX11 COX11 cytochrome c oxidase copper chaperone
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EFNB2 ephrin-B2
EGF epidermal growth factor
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FYB FYN binding protein
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2A2 general transcription factor IIA, 2, 12kDa
HES1 hes family bHLH transcription factor 1
IL6ST interleukin 6 signal transducer
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KRT10 keratin 10, type I
LEF1 lymphoid enhancer-binding factor 1
LOX lysyl oxidase
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MINA MYC induced nuclear antigen
MIR22HG MIR22 host gene
MITF microphthalmia-associated transcription factor
MYL9 myosin, light chain 9, regulatory
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY neuropeptide Y
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDLIM3 PDZ and LIM domain 3
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
PLS1 plastin 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PTRF polymerase I and transcript release factor
RCAN1 regulator of calcineurin 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A46 solute carrier family 25, member 46
SLC39A14 solute carrier family 39 (zinc transporter), member 14
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN8 tetraspanin 8
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB38 zinc finger and BTB domain containing 38