BRD-K93480852_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K93480852_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETV5 ets variant 5
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BC histone cluster 1, H2bc
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM5D lysine (K)-specific demethylase 5D
KLF2 Kruppel-like factor 2
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LIMA1 LIM domain and actin binding 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCOLN1 mucolipin 1
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NPTX2 neuronal pentraxin II
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SYNPO synaptopodin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIB3 tribbles pseudokinase 3
VNN1 vanin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY1 adenylate cyclase 1 (brain)
AURKA aurora kinase A
BCHE butyrylcholinesterase
CA2 carbonic anhydrase II
CCDC92 coiled-coil domain containing 92
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP4A charged multivesicular body protein 4A
CNR1 cannabinoid receptor 1 (brain)
COBL cordon-bleu WH2 repeat protein
CTSV cathepsin V
CTSZ cathepsin Z
FASTKD5 FAST kinase domains 5
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
IGL immunoglobulin lambda locus
KIF20A kinesin family member 20A
LPL lipoprotein lipase
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
METTL3 methyltransferase like 3
MMP9 matrix metallopeptidase 9
PCDH9 protocadherin 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PXMP2 peroxisomal membrane protein 2, 22kDa
REEP1 receptor accessory protein 1
RNF167 ring finger protein 167
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
STRA13 stimulated by retinoic acid 13
STX1A syntaxin 1A (brain)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
XYLT1 xylosyltransferase I
ZIC1 Zic family member 1