BRD-K93215584_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

74 genes differentially expressed following the BRD-K93215584_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
CD44 CD44 molecule (Indian blood group)
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EIF1B eukaryotic translation initiation factor 1B
EPCAM epithelial cell adhesion molecule
FADS1 fatty acid desaturase 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPH1 heat shock 105kDa/110kDa protein 1
IL6R interleukin 6 receptor
IRS2 insulin receptor substrate 2
MDK midkine (neurite growth-promoting factor 2)
MT1M metallothionein 1M
NTS neurotensin
PHLDA2 pleckstrin homology-like domain, family A, member 2
RLF rearranged L-myc fusion
RRAD Ras-related associated with diabetes
S100P S100 calcium binding protein P
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TFF3 trefoil factor 3 (intestinal)
TOB2 transducer of ERBB2, 2
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA2P2 annexin A2 pseudogene 2
BCHE butyrylcholinesterase
CCNB2 cyclin B2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLIC4 chloride intracellular channel 4
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
DPP4 dipeptidyl-peptidase 4
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GRN granulin
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
MAP7 microtubule-associated protein 7
MXRA7 matrix-remodelling associated 7
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
PDIA6 protein disulfide isomerase family A, member 6
PECR peroxisomal trans-2-enoyl-CoA reductase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PON2 paraoxonase 2
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
PXDN peroxidasin
RHOBTB3 Rho-related BTB domain containing 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPON1 spondin 1, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D16 TBC1 domain family, member 16
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TSPAN12 tetraspanin 12
TXNDC9 thioredoxin domain containing 9
WWTR1 WW domain containing transcription regulator 1