BRD-K93060291_TL_HRAS24 BRD-K93060291_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K93060291_TL_HRAS24 BRD-K93060291_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
DUSP8 dual specificity phosphatase 8
EBP emopamil binding protein (sterol isomerase)
ENO2 enolase 2 (gamma, neuronal)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
HEXIM1 hexamethylene bis-acetamide inducible 1
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM4B lysine (K)-specific demethylase 4B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LOC399491
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MACF1 microtubule-actin crosslinking factor 1
MAP4 microtubule-associated protein 4
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
MTA1 metastasis associated 1
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPL1 nucleoporin like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBM25 RNA binding motif protein 25
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RSRC2 arginine/serine-rich coiled-coil 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SETD5 SET domain containing 5
SIAH2 siah E3 ubiquitin protein ligase 2
SIK1 salt-inducible kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC35F2 solute carrier family 35, member F2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
STC2 stanniocalcin 2
TGFBR3 transforming growth factor, beta receptor III
TICAM1 toll-like receptor adaptor molecule 1
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D2 TSC22 domain family, member 2
VGLL4 vestigial-like family member 4
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
BHLHE41 basic helix-loop-helix family, member e41
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CD1E CD1e molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFB complement factor B
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GIMAP6 GTPase, IMAP family member 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAOB monoamine oxidase B
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPTX2 neuronal pentraxin II
NRP1 neuropilin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TSPAN12 tetraspanin 12
TYROBP TYRO protein tyrosine kinase binding protein
WWTR1 WW domain containing transcription regulator 1