BRD-K92571446_WZ-3105_HS578T_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K92571446_WZ-3105_HS578T_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP6 acid phosphatase 6, lysophosphatidic
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
ANXA3 annexin A3
C3 complement component 3
C7 complement component 7
CCL4 chemokine (C-C motif) ligand 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CLEC7A C-type lectin domain family 7, member A
CLNS1A chloride channel, nucleotide-sensitive, 1A
CSRP2 cysteine and glycine-rich protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN1 fibulin 1
FKBP1A FK506 binding protein 1A, 12kDa
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
KIF5C kinesin family member 5C
LCN2 lipocalin 2
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSLN mesothelin
MSMB microseminoprotein, beta-
NEFH neurofilament, heavy polypeptide
NMU neuromedin U
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PI3 peptidase inhibitor 3, skin-derived
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A2 S100 calcium binding protein A2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SOX11 SRY (sex determining region Y)-box 11
SPON1 spondin 1, extracellular matrix protein
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN8 tetraspanin 8
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADM adrenomedullin
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
AURKA aurora kinase A
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DCLRE1C DNA cross-link repair 1C
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK10 dedicator of cytokinesis 10
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
GREM1 gremlin 1, DAN family BMP antagonist
H2AFX H2A histone family, member X
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF11 Kruppel-like factor 11
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MED21 mediator complex subunit 21
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NRN1 neuritin 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTHLH parathyroid hormone-like hormone
PTX3 pentraxin 3, long
RFTN1 raftlin, lipid raft linker 1
RLF rearranged L-myc fusion
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPHK1 sphingosine kinase 1
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF281 zinc finger protein 281