BRD-K92470030_5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide CT-03_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K92470030_5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide CT-03_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CDC20 cell division cycle 20
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLGN calmegin
CRABP1 cellular retinoic acid binding protein 1
CREB1 cAMP responsive element binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FADS1 fatty acid desaturase 1
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
H1FX H1 histone family, member X
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
KLF6 Kruppel-like factor 6
LTBP1 latent transforming growth factor beta binding protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NTS neurotensin
PBX3 pre-B-cell leukemia homeobox 3
PENK proenkephalin
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
APOLD1 apolipoprotein L domain containing 1
BAMBI BMP and activin membrane-bound inhibitor
CALD1 caldesmon 1
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR3 fibroblast growth factor receptor 3
GBP1 guanylate binding protein 1, interferon-inducible
GSN gelsolin
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
LGALS4 lectin, galactoside-binding, soluble, 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PSIP1 PC4 and SFRS1 interacting protein 1
RBPMS RNA binding protein with multiple splicing
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1