BRD-K92428232_GSK-461364_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K92428232_GSK-461364_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACLY ATP citrate lyase
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
CENPE centromere protein E, 312kDa
DCLK1 doublecortin-like kinase 1
EBP emopamil binding protein (sterol isomerase)
EED embryonic ectoderm development
FADS1 fatty acid desaturase 1
FAM50A family with sequence similarity 50, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GPER1 G protein-coupled estrogen receptor 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HDAC6 histone deacetylase 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC10 homeobox C10
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAOB monoamine oxidase B
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
OXSR1 oxidative stress responsive 1
PFKP phosphofructokinase, platelet
PRKCH protein kinase C, eta
PRPF3 pre-mRNA processing factor 3
PRPF6 pre-mRNA processing factor 6
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RUNX3 runt-related transcription factor 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SQLE squalene epoxidase
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TMEM97 transmembrane protein 97
TRIP6 thyroid hormone receptor interactor 6
TSPYL5 TSPY-like 5
XYLT1 xylosyltransferase I
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CD1A CD1a molecule
CD1E CD1e molecule
CD200 CD200 molecule
CD52 CD52 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CFD complement factor D (adipsin)
CHPT1 choline phosphotransferase 1
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
COPA coatomer protein complex, subunit alpha
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL10 chemokine (C-X-C motif) ligand 10
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM60A family with sequence similarity 60, member A
FBN1 fibrillin 1
GPX2 glutathione peroxidase 2
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
HOXA5 homeobox A5
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IL1R1 interleukin 1 receptor, type I
JAG1 jagged 1
KIAA0101 KIAA0101
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LMO4 LIM domain only 4
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
LXN latexin
LYZ lysozyme
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MXRA5 matrix-remodelling associated 5
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NR1H2 nuclear receptor subfamily 1, group H, member 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCNA proliferating cell nuclear antigen
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX9 SRY (sex determining region Y)-box 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTSSA serine palmitoyltransferase, small subunit A
SULF1 sulfatase 1
THBS2 thrombospondin 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
WDR7 WD repeat domain 7
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)