BRD-K92428232_GSK-461364_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K92428232_GSK-461364_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD6 abhydrolase domain containing 6
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CEMIP cell migration inducing protein, hyaluronan binding
CHD7 chromodomain helicase DNA binding protein 7
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
CTSZ cathepsin Z
DLK1 delta-like 1 homolog (Drosophila)
EPHB2 EPH receptor B2
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
FSCN1 fascin actin-bundling protein 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GPRC5B G protein-coupled receptor, class C, group 5, member B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
KCTD5 potassium channel tetramerization domain containing 5
KRT23 keratin 23, type I
KTN1 kinectin 1 (kinesin receptor)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIMS1 LIM and senescent cell antigen-like domains 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYPD1 LY6/PLAUR domain containing 1
MECOM MDS1 and EVI1 complex locus
MMD monocyte to macrophage differentiation-associated
MTA1 metastasis associated 1
MUC16 mucin 16, cell surface associated
PIP prolactin-induced protein
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRRC2C proline-rich coiled-coil 2C
PRSS2 protease, serine, 2 (trypsin 2)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCERG1 transcription elongation regulator 1
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
UBE3C ubiquitin protein ligase E3C
VDAC1 voltage-dependent anion channel 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANOS1 anosmin 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C7 complement component 7
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
COPS7A COP9 signalosome subunit 7A
CRABP1 cellular retinoic acid binding protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIO1 deiodinase, iodothyronine, type I
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
FBP1 fructose-1,6-bisphosphatase 1
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
LGALS3 lectin, galactoside-binding, soluble, 3
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSMB microseminoprotein, beta-
MSRB2 methionine sulfoxide reductase B2
NEBL nebulette
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NISCH nischarin
NPEPL1 aminopeptidase-like 1
NREP neuronal regeneration related protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
RFC2 replication factor C (activator 1) 2, 40kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCCPDH saccharopine dehydrogenase (putative)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFN stratifin
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
SYNGR1 synaptogyrin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
WEE1 WEE1 G2 checkpoint kinase