BRD-K92428232_GSK-461364_A375_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K92428232_GSK-461364_A375_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ATF3 activating transcription factor 3
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
FOXF2 forkhead box F2
GADD45B growth arrest and DNA-damage-inducible, beta
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HIRA histone cell cycle regulator
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IRF8 interferon regulatory factor 8
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
NTS neurotensin
PALLD palladin, cytoskeletal associated protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
REEP5 receptor accessory protein 5
RGS2 regulator of G-protein signaling 2
S100A2 S100 calcium binding protein A2
SFN stratifin
SIK1 salt-inducible kinase 1
SLPI secretory leukocyte peptidase inhibitor
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIP6 thyroid hormone receptor interactor 6
ZDHHC11 zinc finger, DHHC-type containing 11
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
CCNE2 cyclin E2
CCNF cyclin F
CD93 CD93 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CIRBP cold inducible RNA binding protein
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CTSA cathepsin A
CXCL12 chemokine (C-X-C motif) ligand 12
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLK1 delta-like 1 homolog (Drosophila)
EGFL6 EGF-like-domain, multiple 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GAS7 growth arrest-specific 7
GRWD1 glutamate-rich WD repeat containing 1
H1FX H1 histone family, member X
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA1A heat shock 70kDa protein 1A
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ITFG1 integrin alpha FG-GAP repeat containing 1
LRRC41 leucine rich repeat containing 41
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP9 matrix metallopeptidase 9
NLGN4X neuroligin 4, X-linked
NLRP2 NLR family, pyrin domain containing 2
NSG1 neuron specific gene family member 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PMM2 phosphomannomutase 2
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
RPS11 ribosomal protein S11
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUFY3 RUN and FYVE domain containing 3
S100A10 S100 calcium binding protein A10
SAMD4A sterile alpha motif domain containing 4A
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SOX11 SRY (sex determining region Y)-box 11
TARBP1 TAR (HIV-1) RNA binding protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
VCAN versican