BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
CD24 CD24 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F13A1 coagulation factor XIII, A1 polypeptide
FGG fibrinogen gamma chain
GJA1 gap junction protein, alpha 1, 43kDa
HIST2H2BE histone cluster 2, H2be
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1 insulin-like growth factor 1 (somatomedin C)
IL13RA2 interleukin 13 receptor, alpha 2
KRT5 keratin 5, type II
LRRC17 leucine rich repeat containing 17
MMP9 matrix metallopeptidase 9
NSG1 neuron specific gene family member 1
ORM1 orosomucoid 1
PCP4 Purkinje cell protein 4
PLAT plasminogen activator, tissue
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC26A3 solute carrier family 26 (anion exchanger), member 3
THY1 Thy-1 cell surface antigen
TP53TG1 TP53 target 1 (non-protein coding)
VNN1 vanin 1

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AURKA aurora kinase A
BLCAP bladder cancer associated protein
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
EFHD2 EF-hand domain family, member D2
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
HOXC6 homeobox C6
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1S microtubule-associated protein 1S
MED17 mediator complex subunit 17
MTPAP mitochondrial poly(A) polymerase
NET1 neuroepithelial cell transforming 1
NRN1 neuritin 1
NUP98 nucleoporin 98kDa
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
RBM15 RNA binding motif protein 15
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
SASH1 SAM and SH3 domain containing 1
SCAF8 SR-related CTD-associated factor 8
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SMAD3 SMAD family member 3
SNRK SNF related kinase
SOX9 SRY (sex determining region Y)-box 9
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TICAM1 toll-like receptor adaptor molecule 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM97 transmembrane protein 97
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYM2 zinc finger, MYM-type 2