BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ATF3 activating transcription factor 3
BCHE butyrylcholinesterase
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CD52 CD52 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA4 defensin, alpha 4, corticostatin
DHRS2 dehydrogenase/reductase (SDR family) member 2
F12 coagulation factor XII (Hageman factor)
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATAD1 GATA zinc finger domain containing 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ITGA8 integrin, alpha 8
KDM5D lysine (K)-specific demethylase 5D
KIAA0226L KIAA0226-like
LCN2 lipocalin 2
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
ORM1 orosomucoid 1
PCYOX1 prenylcysteine oxidase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKCI protein kinase C, iota
PTPRD protein tyrosine phosphatase, receptor type, D
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RHOQ ras homolog family member Q
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG5 secretogranin V
SDS serine dehydratase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SOCS2 suppressor of cytokine signaling 2
TCF4 transcription factor 4
TYROBP TYRO protein tyrosine kinase binding protein
WISP2 WNT1 inducible signaling pathway protein 2
ZIC1 Zic family member 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADORA2B adenosine A2b receptor
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ARMCX6 armadillo repeat containing, X-linked 6
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CD164 CD164 molecule, sialomucin
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CLTC clathrin, heavy chain (Hc)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FSTL1 follistatin-like 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
MALL mal, T-cell differentiation protein-like
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP85 nucleoporin 85kDa
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PWP1 PWP1 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
REXO2 RNA exonuclease 2
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SMC1A structural maintenance of chromosomes 1A
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TBL1X transducin (beta)-like 1X-linked
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TMX4 thioredoxin-related transmembrane protein 4
TPBG trophoblast glycoprotein
TWF2 twinfilin actin binding protein 2
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP22 ubiquitin specific peptidase 22
XIST X inactive specific transcript (non-protein coding)
ZNF185 zinc finger protein 185 (LIM domain)
ZW10 zw10 kinetochore protein