BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIDA axin interactor, dorsalization associated
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ASPH aspartate beta-hydroxylase
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
EVL Enah/Vasp-like
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFBP1 fibroblast growth factor binding protein 1
FN1 fibronectin 1
FST follistatin
FTO fat mass and obesity associated
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
HAL histidine ammonia-lyase
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IL1RN interleukin 1 receptor antagonist
ISG15 ISG15 ubiquitin-like modifier
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MLF1 myeloid leukemia factor 1
MMP10 matrix metallopeptidase 10
MX1 MX dynamin-like GTPase 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PBX3 pre-B-cell leukemia homeobox 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SPON1 spondin 1, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42SE1 CDC42 small effector 1
CHSY1 chondroitin sulfate synthase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
FGF13 fibroblast growth factor 13
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
JMJD6 jumonji domain containing 6
KDM5B lysine (K)-specific demethylase 5B
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MED13 mediator complex subunit 13
MFSD10 major facilitator superfamily domain containing 10
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NRIP1 nuclear receptor interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
RHOBTB3 Rho-related BTB domain containing 3
RRP1B ribosomal RNA processing 1B
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBX2 T-box 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TRIM2 tripartite motif containing 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
ZMYM2 zinc finger, MYM-type 2
ZNF652 zinc finger protein 652
ZNF91 zinc finger protein 91