BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CDK6 cyclin-dependent kinase 6
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
ESM1 endothelial cell-specific molecule 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXF1 forkhead box F1
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HLA-B major histocompatibility complex, class I, B
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT5 keratin 5, type II
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MMP9 matrix metallopeptidase 9
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NOTCH1 notch 1
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFC platelet derived growth factor C
PLVAP plasmalemma vesicle associated protein
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCARB2 scavenger receptor class B, member 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMC1A structural maintenance of chromosomes 1A
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SST somatostatin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRHDE thyrotropin-releasing hormone degrading enzyme
VCAN versican
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCAS3 breast carcinoma amplified sequence 3
BTBD3 BTB (POZ) domain containing 3
BUB3 BUB3 mitotic checkpoint protein
C14ORF169 chromosome 14 open reading frame 169
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CD164 CD164 molecule, sialomucin
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EED embryonic ectoderm development
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM35A family with sequence similarity 35, member A
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
GLOD4 glyoxalase domain containing 4
GTPBP8 GTP-binding protein 8 (putative)
HEATR1 HEAT repeat containing 1
HMGB2 high mobility group box 2
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
KRT81 keratin 81, type II
KYNU kynureninase
LBR lamin B receptor
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED6 mediator complex subunit 6
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLF1 myeloid leukemia factor 1
MLPH melanophilin
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS30 mitochondrial ribosomal protein S30
MTMR4 myotubularin related protein 4
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NOSIP nitric oxide synthase interacting protein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
OPN3 opsin 3
OXA1L oxidase (cytochrome c) assembly 1-like
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRPF3 pre-mRNA processing factor 3
PRSS23 protease, serine, 23
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTRH2 peptidyl-tRNA hydrolase 2
PUF60 poly-U binding splicing factor 60KDa
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM14 RNA binding motif protein 14
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFC3 replication factor C (activator 1) 3, 38kDa
RNASE4 ribonuclease, RNase A family, 4
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAF8 SR-related CTD-associated factor 8
SFPQ splicing factor proline/glutamine-rich
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SNW1 SNW domain containing 1
SPDEF SAM pointed domain containing ETS transcription factor
SRP54 signal recognition particle 54kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAM transcription factor A, mitochondrial
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM9SF3 transmembrane 9 superfamily member 3
TMEM243 transmembrane protein 243, mitochondrial
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TOB1 transducer of ERBB2, 1
TRIM16 tripartite motif containing 16
TRIM37 tripartite motif containing 37
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
UBL3 ubiquitin-like 3
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
ZDHHC7 zinc finger, DHHC-type containing 7
ZFAND6 zinc finger, AN1-type domain 6
ZMYM2 zinc finger, MYM-type 2