BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
BLNK B-cell linker
BSG basigin (Ok blood group)
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDC42 cell division cycle 42
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GRN granulin
GUK1 guanylate kinase 1
HIST1H2BD histone cluster 1, H2bd
HRSP12 heat-responsive protein 12
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MYOF myoferlin
NEBL nebulette
NUAK1 NUAK family, SNF1-like kinase, 1
ORM1 orosomucoid 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PROSC proline synthetase co-transcribed homolog (bacterial)
PSENEN presenilin enhancer gamma secretase subunit
RGCC regulator of cell cycle
S100A14 S100 calcium binding protein A14
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THBS2 thrombospondin 2
TPD52 tumor protein D52
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABLIM1 actin binding LIM protein 1
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AHCTF1 AT hook containing transcription factor 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASXL2 additional sex combs like transcriptional regulator 2
ATMIN ATM interactor
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC5L cell division cycle 5-like
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP76 centrosomal protein 76kDa
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHSY1 chondroitin sulfate synthase 1
CKAP2 cytoskeleton associated protein 2
CLP1 cleavage and polyadenylation factor I subunit 1
COIL coilin
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EED embryonic ectoderm development
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4B eukaryotic translation initiation factor 4B
ELL2 elongation factor, RNA polymerase II, 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEMIN4 gem (nuclear organelle) associated protein 4
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
IPO7 importin 7
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIAA0232 KIAA0232
KIAA1551 KIAA1551
KIF2A kinesin heavy chain member 2A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LTN1 listerin E3 ubiquitin protein ligase 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MFAP1 microfibrillar-associated protein 1
MFSD5 major facilitator superfamily domain containing 5
MIS12 MIS12 kinetochore complex component
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NPY neuropeptide Y
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PALB2 partner and localizer of BRCA2
PDS5B PDS5 cohesin associated factor B
PHF20 PHD finger protein 20
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLAGL2 pleiomorphic adenoma gene-like 2
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLK4 polo-like kinase 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
PTRH2 peptidyl-tRNA hydrolase 2
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
REST RE1-silencing transcription factor
RIOK2 RIO kinase 2
RLF rearranged L-myc fusion
RNF19B ring finger protein 19B
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEC24A SEC24 family member A
SEC24B SEC24 family member B
SESN1 sestrin 1
SETD2 SET domain containing 2
SETD5 SET domain containing 5
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A44 solute carrier family 25, member 44
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SMG8 SMG8 nonsense mediated mRNA decay factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUCO SUN domain containing ossification factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEFM transcription elongation factor, mitochondrial
TFAM transcription factor A, mitochondrial
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TTK TTK protein kinase
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UMPS uridine monophosphate synthetase
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZDHHC7 zinc finger, DHHC-type containing 7
ZMYM2 zinc finger, MYM-type 2
ZNF146 zinc finger protein 146
ZNF263 zinc finger protein 263