BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

307 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AEBP1 AE binding protein 1
ALOX15B arachidonate 15-lipoxygenase, type B
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
BSG basigin (Ok blood group)
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF5A eukaryotic translation initiation factor 5A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS6 growth arrest-specific 6
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDUA iduronidase, alpha-L-
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR6 lysophosphatidic acid receptor 6
LSP1 lymphocyte-specific protein 1
LUM lumican
MAOA monoamine oxidase A
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NRP1 neuropilin 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
OSBPL10 oxysterol binding protein-like 10
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLXNB2 plexin B2
POSTN periostin, osteoblast specific factor
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE6 ribonuclease, RNase A family, k6
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SDC1 syndecan 1
SEPT2 septin 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM230 transmembrane protein 230
TMEM259 transmembrane protein 259
TNNC1 troponin C type 1 (slow)
TNNI2 troponin I type 2 (skeletal, fast)
TPD52 tumor protein D52
TUSC3 tumor suppressor candidate 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP13A3 ATPase type 13A3
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCOR BCL6 corepressor
BLM Bloom syndrome, RecQ helicase-like
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
C16ORF45 chromosome 16 open reading frame 45
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK13 cyclin-dependent kinase 13
CDK17 cyclin-dependent kinase 17
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP76 centrosomal protein 76kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRTC3 CREB regulated transcription coactivator 3
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD1 EH-domain containing 1
EIF4B eukaryotic translation initiation factor 4B
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FADD Fas (TNFRSF6)-associated via death domain
FAM222B family with sequence similarity 222, member B
FAM46C family with sequence similarity 46, member C
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GCC1 GRIP and coiled-coil domain containing 1
GLUL glutamate-ammonia ligase
GOLPH3L golgi phosphoprotein 3-like
GOSR1 golgi SNAP receptor complex member 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ING3 inhibitor of growth family, member 3
INTS5 integrator complex subunit 5
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KAT7 K(lysine) acetyltransferase 7
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF1BP KIF1 binding protein
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
KYNU kynureninase
LCMT2 leucine carboxyl methyltransferase 2
LDHB lactate dehydrogenase B
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MCM9 minichromosome maintenance complex component 9
MED1 mediator complex subunit 1
MED13 mediator complex subunit 13
MED21 mediator complex subunit 21
MEPCE methylphosphate capping enzyme
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS30 mitochondrial ribosomal protein S30
MRPS35 mitochondrial ribosomal protein S35
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NPAT nuclear protein, ataxia-telangiectasia locus
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PALB2 partner and localizer of BRCA2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE4B phosphodiesterase 4B, cAMP-specific
PFKP phosphofructokinase, platelet
PGRMC2 progesterone receptor membrane component 2
PHF20 PHD finger protein 20
PHF3 PHD finger protein 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP prolactin-induced protein
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRF1 perforin 1 (pore forming protein)
PRPF4B pre-mRNA processing factor 4B
PURA purine-rich element binding protein A
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RBM15 RNA binding motif protein 15
RBM39 RNA binding motif protein 39
RBM48 RNA binding motif protein 48
RCOR1 REST corepressor 1
RGS2 regulator of G-protein signaling 2
RNF111 ring finger protein 111
RNF219 ring finger protein 219
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC24A SEC24 family member A
SEC24B SEC24 family member B
SECISBP2L SECIS binding protein 2-like
SETX senataxin
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SNW1 SNW domain containing 1
SON SON DNA binding protein
SPATA5L1 spermatogenesis associated 5-like 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP1 tyrosyl-DNA phosphodiesterase 1
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53BP2 tumor protein p53 binding protein 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZBTB38 zinc finger and BTB domain containing 38
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF189 zinc finger protein 189
ZNF267 zinc finger protein 267
ZNF281 zinc finger protein 281
ZNF330 zinc finger protein 330
ZNF451 zinc finger protein 451
ZNF473 zinc finger protein 473