BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

261 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOC1 apolipoprotein C-I
AQP9 aquaporin 9
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
C3 complement component 3
C7 complement component 7
CANX calnexin
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CD69 CD69 molecule
CD93 CD93 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CSNK2B casein kinase 2, beta polypeptide
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ESRP1 epithelial splicing regulatory protein 1
FAM198B family with sequence similarity 198, member B
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FRZB frizzled-related protein
FZD6 frizzled class receptor 6
GPM6A glycoprotein M6A
H2BFS H2B histone family, member S (pseudogene)
HAMP hepcidin antimicrobial peptide
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIAA0226L KIAA0226-like
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
ORM1 orosomucoid 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM1 PDZ and LIM domain 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRSS16 protease, serine, 16 (thymus)
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSPH phosphoserine phosphatase
PTTG1IP pituitary tumor-transforming 1 interacting protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGRL SH3 domain binding glutamate-rich protein like
SKP1 S-phase kinase-associated protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SULF1 sulfatase 1
TAGLN transgelin
TDO2 tryptophan 2,3-dioxygenase
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TPSAB1 tryptase alpha/beta 1
TSPAN13 tetraspanin 13
VTCN1 V-set domain containing T cell activation inhibitor 1
WASF1 WAS protein family, member 1
WLS wntless Wnt ligand secretion mediator
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGAP12 Rho GTPase activating protein 12
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPF centromere protein F, 350/400kDa
CEP350 centrosomal protein 350kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP6 charged multivesicular body protein 6
CRCT1 cysteine-rich C-terminal 1
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EED embryonic ectoderm development
EFHD2 EF-hand domain family, member D2
EGFR epidermal growth factor receptor
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
EXOSC4 exosome component 4
F5 coagulation factor V (proaccelerin, labile factor)
FAM102A family with sequence similarity 102, member A
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KRT7 keratin 7, type II
KYNU kynureninase
LONP2 lon peptidase 2, peroxisomal
LPAR1 lysophosphatidic acid receptor 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MFSD5 major facilitator superfamily domain containing 5
MID1 midline 1
MRPS2 mitochondrial ribosomal protein S2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NOP16 NOP16 nucleolar protein
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OXTR oxytocin receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
RAD9A RAD9 homolog A (S. pombe)
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RRAGD Ras-related GTP binding D
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SASH1 SAM and SH3 domain containing 1
SCAF8 SR-related CTD-associated factor 8
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNX11 sorting nexin 11
SPATA2 spermatogenesis associated 2
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TBP TATA box binding protein
TESC tescalcin
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TTF1 transcription termination factor, RNA polymerase I
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
VGLL4 vestigial-like family member 4
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8