BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K92158425_N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ANXA6 annexin A6
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C3 complement component 3
C7 complement component 7
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL4 chemokine (C-C motif) ligand 4
CD14 CD14 molecule
CD177 CD177 molecule
CD52 CD52 molecule
CD69 CD69 molecule
CD83 CD83 molecule
CD99 CD99 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFH complement factor H
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GLT8D2 glycosyltransferase 8 domain containing 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSPH phosphoserine phosphatase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGK1 serum/glucocorticoid regulated kinase 1
STEAP3 STEAP family member 3, metalloreductase
SULF1 sulfatase 1
TCF21 transcription factor 21
TDO2 tryptophan 2,3-dioxygenase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AIM1 absent in melanoma 1
AKAP8 A kinase (PRKA) anchor protein 8
AMD1 adenosylmethionine decarboxylase 1
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ASF1A anti-silencing function 1A histone chaperone
ATP13A3 ATPase type 13A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BCL7B B-cell CLL/lymphoma 7B
BEX1 brain expressed, X-linked 1
C14ORF169 chromosome 14 open reading frame 169
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDK8 cyclin-dependent kinase 8
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CEP350 centrosomal protein 350kDa
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
COIL coilin
CRY1 cryptochrome circadian clock 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDRF1 erythroid differentiation regulatory factor 1
EED embryonic ectoderm development
EFHD2 EF-hand domain family, member D2
EIF4E eukaryotic translation initiation factor 4E
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EMX2 empty spiracles homeobox 2
EXOSC4 exosome component 4
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FBXO28 F-box protein 28
FOSL1 FOS-like antigen 1
GEMIN4 gem (nuclear organelle) associated protein 4
GRWD1 glutamate-rich WD repeat containing 1
GSTP1 glutathione S-transferase pi 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HK1 hexokinase 1
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
INPP1 inositol polyphosphate-1-phosphatase
IPO7 importin 7
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KIF2C kinesin family member 2C
KLHL9 kelch-like family member 9
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KYNU kynureninase
LSG1 large 60S subunit nuclear export GTPase 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
MET MET proto-oncogene, receptor tyrosine kinase
METTL13 methyltransferase like 13
MGLL monoglyceride lipase
MID1 midline 1
MTCL1 microtubule crosslinking factor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NNMT nicotinamide N-methyltransferase
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDS5B PDS5 cohesin associated factor B
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP4R1 protein phosphatase 4, regulatory subunit 1
PRPF4 pre-mRNA processing factor 4
PWP1 PWP1 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RIN2 Ras and Rab interactor 2
RMI1 RecQ mediated genome instability 1
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNX11 sorting nexin 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM11 transmembrane protein 11
TMX4 thioredoxin-related transmembrane protein 4
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAPPC3 trafficking protein particle complex 3
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
TUFT1 tuftelin 1
U2SURP U2 snRNP-associated SURP domain containing
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCPKMT valosin containing protein lysine (K) methyltransferase
WAPAL wings apart-like homolog (Drosophila)
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB11 zinc finger and BTB domain containing 11
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYM2 zinc finger, MYM-type 2
ZNF146 zinc finger protein 146
ZNF22 zinc finger protein 22
ZNF84 zinc finger protein 84