BRD-K91818252_4-(5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid WFM1.17D_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K91818252_4-(5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid WFM1.17D_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AUTS2 autism susceptibility candidate 2
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CKS2 CDC28 protein kinase regulatory subunit 2
HMOX1 heme oxygenase 1
IGLL1 immunoglobulin lambda-like polypeptide 1
ODC1 ornithine decarboxylase 1
PDGFC platelet derived growth factor C
PFKL phosphofructokinase, liver
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
QPRT quinolinate phosphoribosyltransferase
RDX radixin
S100A8 S100 calcium binding protein A8
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SUMO3 small ubiquitin-like modifier 3
TOX3 TOX high mobility group box family member 3
TUBB6 tubulin, beta 6 class V
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOB aldolase B, fructose-bisphosphate
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CCL20 chemokine (C-C motif) ligand 20
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DUOX2 dual oxidase 2
EDN3 endothelin 3
EPS8 epidermal growth factor receptor pathway substrate 8
FGFR1 fibroblast growth factor receptor 1
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
HOPX HOP homeobox
ICT1 immature colon carcinoma transcript 1
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KRT6B keratin 6B, type II
LAMB1 laminin, beta 1
LGALS4 lectin, galactoside-binding, soluble, 4
MATN2 matrilin 2
MMP12 matrix metallopeptidase 12
NES nestin
NFIB nuclear factor I/B
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PDGFD platelet derived growth factor D
PMP22 peripheral myelin protein 22
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRR15L proline rich 15-like
RAI2 retinoic acid induced 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
SAP30BP SAP30 binding protein
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC43A3 solute carrier family 43, member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TRIM2 tripartite motif containing 2
XIST X inactive specific transcript (non-protein coding)
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