BRD-K91449330_1,2-dimethyl (3R)-3-(4-chlorophenyl)-4-oxo-3-(propan-2-yl)-1,2-diazetidine-1,2-dicarboxylate_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K91449330_1,2-dimethyl (3R)-3-(4-chlorophenyl)-4-oxo-3-(propan-2-yl)-1,2-diazetidine-1,2-dicarboxylate_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
CA2 carbonic anhydrase II
CCK cholecystokinin
CD24 CD24 molecule
CST3 cystatin C
DENND2D DENN/MADD domain containing 2D
FAM134B family with sequence similarity 134, member B
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
LDOC1 leucine zipper, down-regulated in cancer 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEGF9 multiple EGF-like-domains 9
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PRSS2 protease, serine, 2 (trypsin 2)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPRO protein tyrosine phosphatase, receptor type, O
SC5D sterol-C5-desaturase
SCML1 sex comb on midleg-like 1 (Drosophila)
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SQSTM1 sequestosome 1
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
COG2 component of oligomeric golgi complex 2
DLK1 delta-like 1 homolog (Drosophila)
F12 coagulation factor XII (Hageman factor)
FAIM Fas apoptotic inhibitory molecule
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
IFI27 interferon, alpha-inducible protein 27
KLF4 Kruppel-like factor 4 (gut)
LPL lipoprotein lipase
LYZ lysozyme
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PDIA6 protein disulfide isomerase family A, member 6
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PXDN peroxidasin
RGS4 regulator of G-protein signaling 4
RTN2 reticulon 2
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZIC1 Zic family member 1