BRD-K91449330_1,2-dimethyl (3R)-3-(4-chlorophenyl)-4-oxo-3-(propan-2-yl)-1,2-diazetidine-1,2-dicarboxylate_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K91449330_1,2-dimethyl (3R)-3-(4-chlorophenyl)-4-oxo-3-(propan-2-yl)-1,2-diazetidine-1,2-dicarboxylate_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BAG2 BCL2-associated athanogene 2
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD70 CD70 molecule
CNPY3 canopy FGF signaling regulator 3
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
GCLM glutamate-cysteine ligase, modifier subunit
GUSBP3 glucuronidase, beta pseudogene 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IL6 interleukin 6
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KYNU kynureninase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MUC4 mucin 4, cell surface associated
NCAM1 neural cell adhesion molecule 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTN pleiotrophin
RAB2A RAB2A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RPL38 ribosomal protein L38
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SVIL supervillin
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ARMCX2 armadillo repeat containing, X-linked 2
AUTS2 autism susceptibility candidate 2
CALB1 calbindin 1, 28kDa
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CD24 CD24 molecule
DCT dopachrome tautomerase
DUSP2 dual specificity phosphatase 2
EPHA4 EPH receptor A4
FGFR2 fibroblast growth factor receptor 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
KRT7 keratin 7, type II
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PSPH phosphoserine phosphatase
RANBP1 RAN binding protein 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)