BRD-K91370081_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K91370081_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD28 ankyrin repeat domain 28
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATF6 activating transcription factor 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BRD2 bromodomain containing 2
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CLK4 CDC-like kinase 4
COL11A1 collagen, type XI, alpha 1
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK1A1 casein kinase 1, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL6 interleukin 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INPP1 inositol polyphosphate-1-phosphatase
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MTUS1 microtubule associated tumor suppressor 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
QKI QKI, KH domain containing, RNA binding
RAB5A RAB5A, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RAE1 ribonucleic acid export 1
RB1CC1 RB1-inducible coiled-coil 1
RBBP6 retinoblastoma binding protein 6
RBM39 RNA binding motif protein 39
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SIK3 SIK family kinase 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERF2IP telomeric repeat binding factor 2, interacting protein
TFE3 transcription factor binding to IGHM enhancer 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP1 topoisomerase (DNA) I
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
U2SURP U2 snRNP-associated SURP domain containing
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBXN4 UBX domain protein 4
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WAC WW domain containing adaptor with coiled-coil
WSB1 WD repeat and SOCS box containing 1
WT1 Wilms tumor 1
YTHDC1 YTH domain containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZBTB43 zinc finger and BTB domain containing 43
ZC3H11A zinc finger CCCH-type containing 11A
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ADSL adenylosuccinate lyase
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA4 annexin A4
BID BH3 interacting domain death agonist
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CADPS2 Ca++-dependent secretion activator 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC86 coiled-coil domain containing 86
CD14 CD14 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLC Charcot-Leyden crystal galectin
CPB1 carboxypeptidase B1 (tissue)
CSTA cystatin A (stefin A)
DPYSL2 dihydropyrimidinase-like 2
EIF4B eukaryotic translation initiation factor 4B
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HEBP2 heme binding protein 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
ITGB1BP1 integrin beta 1 binding protein 1
LINC00341 long intergenic non-protein coding RNA 341
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MFSD10 major facilitator superfamily domain containing 10
MLPH melanophilin
MPZL2 myelin protein zero-like 2
MSH6 mutS homolog 6
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PDCD2 programmed cell death 2
PGK1 phosphoglycerate kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPA1 replication protein A1, 70kDa
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMM50 SAMM50 sorting and assembly machinery component
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNN stannin
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBR3 transforming growth factor, beta receptor III
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TPD52L1 tumor protein D52-like 1
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UNG uracil-DNA glycosylase
VGLL1 vestigial-like family member 1
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1