BRD-K91134378_Furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-methanone MLS-0083944.0001_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K91134378_Furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-methanone MLS-0083944.0001_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTC1 actin, alpha, cardiac muscle 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CSTA cystatin A (stefin A)
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMX2 empty spiracles homeobox 2
EPN2 epsin 2
ESR1 estrogen receptor 1
FBN2 fibrillin 2
FZD10 frizzled class receptor 10
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
MATN2 matrilin 2
MPPED2 metallophosphoesterase domain containing 2
NEB nebulin
PERP PERP, TP53 apoptosis effector
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTN pleiotrophin
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SIX1 SIX homeobox 1
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TNNT1 troponin T type 1 (skeletal, slow)
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BASP1 brain abundant, membrane attached signal protein 1
C1S complement component 1, s subcomponent
C2CD2 C2 calcium-dependent domain containing 2
C7 complement component 7
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
COL10A1 collagen, type X, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYCS cytochrome c, somatic
FBN1 fibrillin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FRZB frizzled-related protein
GAS1 growth arrest-specific 1
GSTM3 glutathione S-transferase mu 3 (brain)
HEG1 heart development protein with EGF-like domains 1
HOXC6 homeobox C6
IFI30 interferon, gamma-inducible protein 30
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
LHFP lipoma HMGIC fusion partner
LY75 lymphocyte antigen 75
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MXRA8 matrix-remodelling associated 8
PDE1A phosphodiesterase 1A, calmodulin-dependent
PHF20 PHD finger protein 20
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PTK2 protein tyrosine kinase 2
S100A10 S100 calcium binding protein A10
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOAT1 sterol O-acyltransferase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
TMEM97 transmembrane protein 97
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8