BRD-K90999434_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-K90999434_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
AMACR alpha-methylacyl-CoA racemase
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CCL4 chemokine (C-C motif) ligand 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
E2F2 E2F transcription factor 2
FADS1 fatty acid desaturase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IL1RN interleukin 1 receptor antagonist
IQGAP2 IQ motif containing GTPase activating protein 2
KIF14 kinesin family member 14
LDHB lactate dehydrogenase B
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSX1 msh homeobox 1
NTS neurotensin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
SIRT3 sirtuin 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FGFR2 fibroblast growth factor receptor 2
FKBP4 FK506 binding protein 4, 59kDa
FN1 fibronectin 1
FRZB frizzled-related protein
GREM1 gremlin 1, DAN family BMP antagonist
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
ISOC1 isochorismatase domain containing 1
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LYZ lysozyme
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
ORC1 origin recognition complex, subunit 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)