BRD-K90735586_5-PHENYL-4,7-DIHYDROTETRAAZOLO[1,5-A]PYRIMIDINE (Compound C)_CL34_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K90735586_5-PHENYL-4,7-DIHYDROTETRAAZOLO[1,5-A]PYRIMIDINE (Compound C)_CL34_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
APMAP adipocyte plasma membrane associated protein
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
CA2 carbonic anhydrase II
CCND2 cyclin D2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CETN2 centrin, EF-hand protein, 2
COL1A2 collagen, type I, alpha 2
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
DDR2 discoidin domain receptor tyrosine kinase 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
EFNB2 ephrin-B2
FAM129A family with sequence similarity 129, member A
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAS GNAS complex locus
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMGB3 high mobility group box 3
HOMER3 homer scaffolding protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIF5C kinesin family member 5C
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LMNA lamin A/C
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MFSD10 major facilitator superfamily domain containing 10
MGP matrix Gla protein
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTA1 metastasis associated 1
NES nestin
PBX1 pre-B-cell leukemia homeobox 1
PRSS2 protease, serine, 2 (trypsin 2)
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STC1 stanniocalcin 1
TARP TCR gamma alternate reading frame protein
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCF4 transcription factor 4
TES testin LIM domain protein
TF transferrin
TM4SF4 transmembrane 4 L six family member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN5 tetraspanin 5
VGLL4 vestigial-like family member 4
VIM vimentin
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
AMD1 adenosylmethionine decarboxylase 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AREG amphiregulin
ARMCX3 armadillo repeat containing, X-linked 3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATG3 autophagy related 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BIRC3 baculoviral IAP repeat containing 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
C9ORF3 chromosome 9 open reading frame 3
CD52 CD52 molecule
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
COX5A cytochrome c oxidase subunit Va
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
EBNA1BP2 EBNA1 binding protein 2
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM134B family with sequence similarity 134, member B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GDF15 growth differentiation factor 15
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPRC5A G protein-coupled receptor, class C, group 5, member A
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXB6 homeobox B6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO7 importin 7
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0101 KIAA0101
KRT14 keratin 14, type I
LAMP3 lysosomal-associated membrane protein 3
LPIN1 lipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MOAP1 modulator of apoptosis 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTUS1 microtubule associated tumor suppressor 1
NAP1L1 nucleosome assembly protein 1-like 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
OSBPL10 oxysterol binding protein-like 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP prolactin-induced protein
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLS1 plastin 1
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCAN1 regulator of calcineurin 1
RPL36AL ribosomal protein L36a-like
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SF1 splicing factor 1
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMS spermine synthase
SNAP23 synaptosomal-associated protein, 23kDa
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
STXBP2 syntaxin binding protein 2
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM2D3 TM2 domain containing 3
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP1 ubiquitin specific peptidase 1
YME1L1 YME1-like 1 ATPase