BRD-K90735586_5-PHENYL-4,7-DIHYDROTETRAAZOLO[1,5-A]PYRIMIDINE (Compound C)_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K90735586_5-PHENYL-4,7-DIHYDROTETRAAZOLO[1,5-A]PYRIMIDINE (Compound C)_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CEP57 centrosomal protein 57kDa
CFD complement factor D (adipsin)
CHGB chromogranin B
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DAZAP2 DAZ associated protein 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EHD3 EH-domain containing 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FKBP4 FK506 binding protein 4, 59kDa
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS2 growth arrest-specific 2
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
ITM2B integral membrane protein 2B
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
KRT23 keratin 23, type I
LITAF lipopolysaccharide-induced TNF factor
LYZ lysozyme
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MFAP5 microfibrillar associated protein 5
MPO myeloperoxidase
MREG melanoregulin
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OSBPL10 oxysterol binding protein-like 10
PCSK1 proprotein convertase subtilisin/kexin type 1
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PON3 paraoxonase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSCA prostate stem cell antigen
PTPRO protein tyrosine phosphatase, receptor type, O
RAD51AP1 RAD51 associated protein 1
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SCRN1 secernin 1
SDC1 syndecan 1
SGCE sarcoglycan, epsilon
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SULF1 sulfatase 1
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TNNT1 troponin T type 1 (skeletal, slow)
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TRAM1 translocation associated membrane protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
AGR2 anterior gradient 2
ARL4A ADP-ribosylation factor-like 4A
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CNOT7 CCR4-NOT transcription complex, subunit 7
CRTC3 CREB regulated transcription coactivator 3
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
EFNB2 ephrin-B2
ERBB2 erb-b2 receptor tyrosine kinase 2
FASTKD5 FAST kinase domains 5
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
HLTF helicase-like transcription factor
IL6ST interleukin 6 signal transducer
IPO13 importin 13
IQGAP2 IQ motif containing GTPase activating protein 2
KIF1B kinesin family member 1B
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
MAGED1 melanoma antigen family D1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
NAV3 neuron navigator 3
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
PCDH9 protocadherin 9
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA1 paraneoplastic Ma antigen 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RPS11 ribosomal protein S11
RSAD1 radical S-adenosyl methionine domain containing 1
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMYD3 SET and MYND domain containing 3
SQLE squalene epoxidase
STARD13 StAR-related lipid transfer (START) domain containing 13
TESC tescalcin
TOB2 transducer of ERBB2, 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
WSB1 WD repeat and SOCS box containing 1
ZBTB38 zinc finger and BTB domain containing 38