BRD-K90382497_GW-843682X_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K90382497_GW-843682X_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
BIN1 bridging integrator 1
C1ORF106 chromosome 1 open reading frame 106
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSRP1 cysteine and glycine-rich protein 1
DENND2D DENN/MADD domain containing 2D
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FERMT2 fermitin family member 2
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GOLGA8A golgin A8 family, member A
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER2 immediate early response 2
IFI6 interferon, alpha-inducible protein 6
KLF6 Kruppel-like factor 6
LYN LYN proto-oncogene, Src family tyrosine kinase
MB myoglobin
NPTX2 neuronal pentraxin II
PDLIM5 PDZ and LIM domain 5
PPOX protoporphyrinogen oxidase
RHOB ras homolog family member B
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPEN spen family transcriptional repressor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRRM2 serine/arginine repetitive matrix 2
TES testin LIM domain protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM2 tropomyosin 2 (beta)
TRAF5 TNF receptor-associated factor 5
VIM vimentin
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
COL15A1 collagen, type XV, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
DPP4 dipeptidyl-peptidase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERAP2 endoplasmic reticulum aminopeptidase 2
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LYZ lysozyme
MAL mal, T-cell differentiation protein
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PRKCD protein kinase C, delta
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
VAT1 vesicle amine transport 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase