BRD-K90382497_GW-843682X_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K90382497_GW-843682X_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AMIGO2 adhesion molecule with Ig-like domain 2
ASRGL1 asparaginase like 1
AUTS2 autism susceptibility candidate 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BLNK B-cell linker
CALML4 calmodulin-like 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL5A2 collagen, type V, alpha 2
CPM carboxypeptidase M
CYB5R2 cytochrome b5 reductase 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FGFR2 fibroblast growth factor receptor 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBE1 hemoglobin, epsilon 1
HIST1H2BG histone cluster 1, H2bg
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
KAZN kazrin, periplakin interacting protein
LOC100505650 uncharacterized LOC100505650
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
OBSL1 obscurin-like 1
PXDN peroxidasin
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SET SET nuclear proto-oncogene
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STS steroid sulfatase (microsomal), isozyme S
STX1A syntaxin 1A (brain)
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TMCC1 transmembrane and coiled-coil domain family 1
TNS3 tensin 3
TPM4 tropomyosin 4
TRIM2 tripartite motif containing 2
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD28 ankyrin repeat domain 28
ASCL1 achaete-scute family bHLH transcription factor 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BEX1 brain expressed, X-linked 1
C8ORF4 chromosome 8 open reading frame 4
CCL19 chemokine (C-C motif) ligand 19
CCNB1 cyclin B1
CCNE2 cyclin E2
CD69 CD69 molecule
CEP350 centrosomal protein 350kDa
CHI3L2 chitinase 3-like 2
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
DUSP10 dual specificity phosphatase 10
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F8 coagulation factor VIII, procoagulant component
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
GLIPR1 GLI pathogenesis-related 1
HOMER1 homer scaffolding protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KYNU kynureninase
LPL lipoprotein lipase
MGP matrix Gla protein
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMB neuromedin B
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PFKP phosphofructokinase, platelet
PIP prolactin-induced protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRDX4 peroxiredoxin 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTTG1 pituitary tumor-transforming 1
RGS5 regulator of G-protein signaling 5
RNF167 ring finger protein 167
SELE selectin E
SELL selectin L
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SYNM synemin, intermediate filament protein
TJP2 tight junction protein 2
TNPO1 transportin 1
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRH ubiquinol-cytochrome c reductase hinge protein