BRD-K90382497_GW-843682X_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K90382497_GW-843682X_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT1 angiopoietin 1
ARHGAP29 Rho GTPase activating protein 29
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BAG2 BCL2-associated athanogene 2
C21ORF33 chromosome 21 open reading frame 33
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CP ceruloplasmin (ferroxidase)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
FASTKD1 FAST kinase domains 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGB fibrinogen beta chain
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATA3 GATA binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JMJD6 jumonji domain containing 6
LEPR leptin receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
NAP1L3 nucleosome assembly protein 1-like 3
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NRP1 neuropilin 1
ODAM odontogenic, ameloblast asssociated
PCDH9 protocadherin 9
PER3 period circadian clock 3
PLK2 polo-like kinase 2
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
RBKS ribokinase
REEP5 receptor accessory protein 5
RPP38 ribonuclease P/MRP 38kDa subunit
S100A10 S100 calcium binding protein A10
SDC2 syndecan 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TRBC1 T cell receptor beta constant 1
TYRP1 tyrosinase-related protein 1
VCAN versican

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CCNG2 cyclin G2
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFLAR CASP8 and FADD-like apoptosis regulator
CPM carboxypeptidase M
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
FKBP14 FK506 binding protein 14, 22 kDa
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
H1FX H1 histone family, member X
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
ITM2C integral membrane protein 2C
KLK6 kallikrein-related peptidase 6
KRT23 keratin 23, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LITAF lipopolysaccharide-induced TNF factor
MDK midkine (neurite growth-promoting factor 2)
MSH6 mutS homolog 6
NCAM1 neural cell adhesion molecule 1
NCAPD3 non-SMC condensin II complex, subunit D3
NDRG2 NDRG family member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PDZRN3 PDZ domain containing ring finger 3
PLAT plasminogen activator, tissue
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD51AP1 RAD51 associated protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SPON1 spondin 1, extracellular matrix protein
STAT1 signal transducer and activator of transcription 1, 91kDa
TACSTD2 tumor-associated calcium signal transducer 2
TCF21 transcription factor 21
TFPI2 tissue factor pathway inhibitor 2
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TRAF5 TNF receptor-associated factor 5
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VCAM1 vascular cell adhesion molecule 1
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A