BRD-K90382497_GW-843682X_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K90382497_GW-843682X_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATF5 activating transcription factor 5
ATG12 autophagy related 12
AURKA aurora kinase A
C4BPA complement component 4 binding protein, alpha
CAB39 calcium binding protein 39
CCND2 cyclin D2
CDC20 cell division cycle 20
CENPE centromere protein E, 312kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
COL2A1 collagen, type II, alpha 1
DEPDC1 DEP domain containing 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FHL1 four and a half LIM domains 1
FNTA farnesyltransferase, CAAX box, alpha
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPM6B glycoprotein M6B
GPR171 G protein-coupled receptor 171
GPSM2 G-protein signaling modulator 2
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGA6 integrin, alpha 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LEFTY1 left-right determination factor 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MFAP3L microfibrillar-associated protein 3-like
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1X metallothionein 1X
MTF2 metal response element binding transcription factor 2
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARP8 poly (ADP-ribose) polymerase family, member 8
PCTP phosphatidylcholine transfer protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMM2 phosphomannomutase 2
PRKCH protein kinase C, eta
PSRC1 proline/serine-rich coiled-coil 1
RGS10 regulator of G-protein signaling 10
RTCA RNA 3'-terminal phosphate cyclase
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TBL1X transducin (beta)-like 1X-linked
THBS4 thrombospondin 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VAMP8 vesicle-associated membrane protein 8
VAV3 vav 3 guanine nucleotide exchange factor
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CD59 CD59 molecule, complement regulatory protein
CDC45 cell division cycle 45
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFB complement factor B
CHPT1 choline phosphotransferase 1
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DUSP2 dual specificity phosphatase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FADS1 fatty acid desaturase 1
FBXO11 F-box protein 11
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXYD2 FXYD domain containing ion transport regulator 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LINC00342 long intergenic non-protein coding RNA 342
LYZ lysozyme
MAP7 microtubule-associated protein 7
MARC2 mitochondrial amidoxime reducing component 2
MEGF9 multiple EGF-like-domains 9
MSMO1 methylsterol monooxygenase 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNT nicotinamide nucleotide transhydrogenase
NREP neuronal regeneration related protein
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAIP1 poly(A) binding protein interacting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
RGS5 regulator of G-protein signaling 5
RHOBTB1 Rho-related BTB domain containing 1
RNASE4 ribonuclease, RNase A family, 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SUB1 SUB1 homolog (S. cerevisiae)
SULF1 sulfatase 1
TCTN1 tectonic family member 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOPBP1 topoisomerase (DNA) II binding protein 1
TUSC3 tumor suppressor candidate 3
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1