BRD-K90382497_GW-843682X_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K90382497_GW-843682X_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CCNB2 cyclin B2
CDC42SE1 CDC42 small effector 1
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6B glycoprotein M6B
HACD3 3-hydroxyacyl-CoA dehydratase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1RAP interleukin 1 receptor accessory protein
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF14 kinesin family member 14
KLHDC10 kelch domain containing 10
LIMS1 LIM and senescent cell antigen-like domains 1
LPAR6 lysophosphatidic acid receptor 6
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MT1M metallothionein 1M
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NPTX2 neuronal pentraxin II
OSBPL3 oxysterol binding protein-like 3
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE9A phosphodiesterase 9A
PDPN podoplanin
PGBD5 piggyBac transposable element derived 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD21 RAD21 homolog (S. pombe)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
SST somatostatin
SYBU syntabulin (syntaxin-interacting)
TBL1X transducin (beta)-like 1X-linked
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TPPP3 tubulin polymerization-promoting protein family member 3
TWIST1 twist family bHLH transcription factor 1
UFM1 ubiquitin-fold modifier 1
VSIG4 V-set and immunoglobulin domain containing 4
WASF3 WAS protein family, member 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AEBP1 AE binding protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C10ORF10 chromosome 10 open reading frame 10
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDK4 cyclin-dependent kinase 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CLU clusterin
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FADS2 fatty acid desaturase 2
GAS1 growth arrest-specific 1
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP11 glucuronidase, beta pseudogene 11
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KIAA0485 uncharacterized LOC57235
LAMA3 laminin, alpha 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
LTBP3 latent transforming growth factor beta binding protein 3
LYZ lysozyme
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MMP11 matrix metallopeptidase 11
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
NREP neuronal regeneration related protein
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PEG10 paternally expressed 10
PGD phosphogluconate dehydrogenase
PGRMC1 progesterone receptor membrane component 1
PLCB4 phospholipase C, beta 4
PLXNC1 plexin C1
RGS5 regulator of G-protein signaling 5
RUFY3 RUN and FYVE domain containing 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SLC16A4 solute carrier family 16, member 4
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
SVIL supervillin
TM7SF2 transmembrane 7 superfamily member 2
TRIM22 tripartite motif containing 22
ZDHHC6 zinc finger, DHHC-type containing 6