BRD-K90382497_GW-843682X_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K90382497_GW-843682X_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AUTS2 autism susceptibility candidate 2
BGN biglycan
CADM1 cell adhesion molecule 1
CCK cholecystokinin
CCL4 chemokine (C-C motif) ligand 4
CES1 carboxylesterase 1
CLDN10 claudin 10
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CPM carboxypeptidase M
EIF5 eukaryotic translation initiation factor 5
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPX7 glutathione peroxidase 7
ICAM1 intercellular adhesion molecule 1
IL1B interleukin 1, beta
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNK3 potassium channel, two pore domain subfamily K, member 3
LYRM1 LYR motif containing 1
MET MET proto-oncogene, receptor tyrosine kinase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
NEFL neurofilament, light polypeptide
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
OLFM1 olfactomedin 1
OLFML2B olfactomedin-like 2B
PECR peroxisomal trans-2-enoyl-CoA reductase
POSTN periostin, osteoblast specific factor
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TGM2 transglutaminase 2
THBS2 thrombospondin 2
TSPAN13 tetraspanin 13
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
BCAP31 B-cell receptor-associated protein 31
CALML5 calmodulin-like 5
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA2 chloride channel accessory 2
CLCA4 chloride channel accessory 4
CLPTM1 cleft lip and palate associated transmembrane protein 1
CST3 cystatin C
CSTA cystatin A (stefin A)
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSC3 desmocollin 3
DSG1 desmoglein 1
DUOX2 dual oxidase 2
FABP4 fatty acid binding protein 4, adipocyte
FKBP4 FK506 binding protein 4, 59kDa
FXYD3 FXYD domain containing ion transport regulator 3
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
HHEX hematopoietically expressed homeobox
HMGB3 high mobility group box 3
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPD3 LY6/PLAUR domain containing 3
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
NID1 nidogen 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PI3 peptidase inhibitor 3, skin-derived
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
RHOBTB3 Rho-related BTB domain containing 3
S100A7 S100 calcium binding protein A7
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SNCAIP synuclein, alpha interacting protein
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRR1A small proline-rich protein 1A
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE4 transducin-like enhancer of split 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
TYRP1 tyrosinase-related protein 1
WLS wntless Wnt ligand secretion mediator